10 research outputs found
Extended right posterior liver sectionectomy for HCC in a patient with left ventricular assist device—a case report
Successful implementation of left ventricular assist devices lead to a prolonged survival in patients with chronic terminal heart failure. Thus, patients with pre-existing left ventricular assist devices with abdominal comorbidities requiring abdominal surgery, e.g. for malignancy, are upcoming issues. We carried out a major liver resection for hepatocellular carcinoma in a patient with pre-existing left ventricular assist device. The importance of this case report is that it outlines the significance of oncologic resections in patients with left ventricular assist devices as an upcoming issue and provides an interdisciplinary approach
Sodium Thiosulfate Reduces Acute Kidney Injury in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy with Cisplatin: A Single-Center Observational Study
Background: Cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a multimodal treatment concept for patients with peritoneal surface malignancies. The use of intraperitoneal cisplatin (CDDP) is associated with a risk of acute kidney injury (AKI). The aim of this study is to evaluate the protective effect of perioperative sodium thiosulfate (STS) administration on kidney function in patients undergoing CRS and CDDP-based HIPEC.
Patients and Methods: We retrospectively analyzed clinical data of all patients who underwent CRS and CDDP-based HIPEC at our hospital between March 2017 and August 2020. Patients were stratified according to the use of sodium thiosulfate (STS vs. no STS). We compared kidney function and clinical outcome parameters between both groups and determined risk factors for postoperative AKI on univariate and multivariate analysis. AKI was classified according to acute kidney injury network (AKIN) criteria.
Results: Of 238 patients who underwent CRS and CDDP-based HIPEC, 46 patients received STS and 192 patients did not. There were no significant differences in baseline characteristics. In patients who received STS, a lower incidence (6.5% vs. 30.7%; p = 0.001) and severity of AKI (p = 0.009) were observed. On multivariate analysis, the use of STS (OR 0.089, p = 0.001) remained an independent kidney-protective factor, while arterial hypertension (OR 5.283, p < 0.001) and elevated preoperative urea serum level (OR 5.278, p = 0.032) were predictors for postoperative AKI.
Conclusions: The present data suggest that STS protects patients from AKI caused by CRS and CDDP-based HIPEC. Further prospective studies are needed to validate the benefit of STS among kidney-protective strategies
Photon shot-noise limited transient absorption soft X-ray spectroscopy at the European XFEL
Femtosecond transient soft X-ray Absorption Spectroscopy (XAS) is a very
promising technique that can be employed at X-ray Free Electron Lasers (FELs)
to investigate out-of-equilibrium dynamics for material and energy research.
Here we present a dedicated setup for soft X-rays available at the Spectroscopy
& Coherent Scattering (SCS) instrument at the European X-ray Free Electron
Laser (EuXFEL). It consists of a beam-splitting off-axis zone plate (BOZ) used
in transmission to create three copies of the incoming beam, which are used to
measure the transmitted intensity through the excited and unexcited sample, as
well as to monitor the incoming intensity. Since these three intensity signals
are detected shot-by-shot and simultaneously, this setup allows normalized
shot-by-shot analysis of the transmission. For photon detection, the DSSC
imaging detector, which is capable of recording up to 800 images at 4.5 MHz
frame rate during the FEL burst, is employed and allows approaching the photon
shot-noise limit. We review the setup and its capabilities, as well as the
online and offline analysis tools provided to users.Comment: 11 figure
A PGAS-based Implementation for the Unstructured CFD Solver TAU
Whereas most applications in the realm of the partitioned
global address space make use of PGAS languages we here
demonstrate an implementation on top of a PGAS-API. In
order to improve the scalability of the unstructured CFD
solver TAU we have implemented an asynchronous communication strategy on top of the PGAS-API of GPI. We have replaced the bulk-synchronous two-sided MPI exchange with an asynchronous, RDMA-driven, one-sided communication
pattern. We also have developed an asynchronous shared memory strategy for the TAU solver. We demonstrate that
the corresponding implementation not only scales one order
of magnitude higher than the original MPI implementation,
but that it also outperforms the hybrid OpenMP/MPI programming model
The interplay of local electron correlations and ultrafast spin dynamics in fcc Ni
The complex electronic structure of metallic ferromagnets is determined by a balance between exchange interaction, electron hopping leading to band formation, and local Coulomb repulsion. By combining high energy and temporal resolution in femtosecond time-resolved X-ray absorption spectroscopy with ab initio time-dependent density functional theory we analyze the electronic structure in fcc Ni on the time scale of these interactions in a pump-probe experiment. We distinguish transient broadening and energy shifts in the absorption spectra, which we demonstrate to be captured by electron repopulation respectively correlation-induced modifications of the electronic structure, requiring to take the local Coulomb interaction into account.ISSN:2166-383
GASPI – A Partitioned Global Address Space Programming Interface
At the threshold to exascale computing, limitations of the MPI programming model become more and more pronounced. HPC programmers have to design codes that can run and scale on systems with hundreds of thousands of cores. Setting up accordingly many communication buffers, point-to-point communication links, and using bulk-synchronous communication phases is contradicting scalability in these dimensions. Moreover, the reliability of upcoming systems will worsen
The interplay of local electron correlations and ultrafast spin dynamics in fcc Ni
The complex electronic structure of metallic ferromagnets is determined by a balance between exchange interaction, electron hopping leading to band formation, and local Coulomb repulsion. By combining high energy and temporal resolution in femtosecond time-resolved X-ray absorption spectroscopy with ab initio time-dependent density functional theory we analyze the electronic structure in fcc Ni on the time scale of these interactions in a pump-probe experiment. We distinguish transient broadening and energy shifts in the absorption spectra, which we demonstrate to be captured by electron repopulation respectively correlation-induced modifications of the electronic structure, requiring to take the local Coulomb interaction into account